Irisin

Background: Transmembrane protein fibronectin type III domain-containing protein 5 (FNDC5) is as a myokine, metabolic regulator and potential therapeutic agent which is known as a potential trait for metabolism and obesity. Aim: The purpose of this study was to evaluate the effect of high intensity interval swimming training on circulating irisin and some metabolic syndrome in postmenopausal overweight women. Materials and Methods: Thirty postmenopausal overweight women (55.73 ± 2.66 years, 26.72±2.33 kg/m 2 ) were randomized into high intensity interval swimming training (n=15; HIIT) and control groups (n=15; CON). HIIT performed 6–10×30 s swimming interspersed by 2 min recovery for an 8-week period completing 24±1 session (average heart rate= 0.89±0.029% HRmax). Fasting blood samples were taken and body mass index was measured pre- and post-intervention. Results : In CON, there was not significant change in all measured variables before and after the intervention period. Irisin increased ( P <0.01) by 0.64±0.27 mg/ml in HIIT group. Insulin decreased ( P <0.01) by 0.96±0.36 mg/dl while the blood lipid profile P = 0.78 cholesterol, P =0.14 TG, P =0.10 HDL, P =0.52 LDL, systolic blood pressure ( P = 0.51), dyastolic blood pressure ( P = 0.75), and BMI ( P = 0.87) were unaltered. Conclusion: The result of present study showed that high intensity interval swimming trainings is an effectual and time-efficient training way for increasing irisin, and it can lead to compensatory irisin increases in postmenopausal overweight women.

Purpose: The aim of this study was to compare the effect of eight weeks of aerobic, resistance and combination training on serum levels of irizin, atherogenic index of plasma (AIP) and some cardiovascular risk factors in inactive overweight men. Methods: In this quasi-experimental study, 32 inactive overweight men participated voluntarily and were randomly divided into 4 groups: aerobic training, resistance training, combination training and control. Serum levels of irizin, AIP and lipid profile of subjects were measured before and after eight weeks of exercise. Results : After eight weeks of exercise intervention, irizin levels increased significantly in all three experimental groups (P <0.05). Also, AIP decreased significantly in all three training groups (P <0.05). On the other hand, in examining the differences between groups, a significant difference was observed between the groups in AIP and irisin (P <0.05). Conclusion: The results of the present study showed that eight weeks of exercise training can possibly cause favorable changes in plasma irisin and biochemical parameters of the blood in overweight people. Also, combined training seems to have more favorable effects than other training methods.

Purpose: The aim of this study was to investigate the effect of high-intensity interval training on serum levels of irisin, follistatin, and metabolic status of overweight and obese women. Methods: The current research was a semi-experimental type with a pre and post-test design. 30 women with an average age of 22.9±2.11 years, weight 82.45±6.1 kg, BMI above 28 kg/m2) voluntarily participated and they were randomly divided into two groups of 15 people including HIIT (4 bouts of 60 seconds of running at an intensity of 80-90% HRmax with a 4-minute rest in the first four weeks) and control (did not have a regular exercise program). Blood samples were taken 24 hours before the start of the training period and 48 hours after the end of the last session, to measure irisin, Follistatin, and metabolic status, by ELISA method. Then, an independent t-test was used to examine changes between groups, and a correlated t-test was used for intragroup comparison. Data analysis was done by SPSS version 25 software at a significance level of 0.05. Results: After 8 weeks of intervention, the HIIT group showed that HIIT exercises led to a significant increase in irisin(p=0.25) and follistatin(p=0.12), triglyceride (p=0.30), and total cholesterol levels. (p=0.41), LDL (p=0.14), VLDL (p=0.17), weight (p=0.31), fat percentage (p =0.21)) and BMI (p=0.251); And there was a significant increase in maximum oxygen consumption (p=0.11). However, no significant change was observed in the amount of HDL (p=0.55). Conclusion: According to the findings of the present study, in order to maintain or prevent the decrease in bone density of postmenopausal women, resistance exercises can be recommended.